Sexually transmitted infections (STIs) remain a significant public health concern globally, particularly among young adults, including university students. This study aims to assess the level of knowledge, awareness, and attitudes towards STIs among university students. Using a mixed-methods approach, both quantitative and qualitative data were collected through surveys and focus group discussions across multiple universities. The findings reveal a moderate level of awareness regarding common STIs such as HIV, chlamydia, and gonorrhea, but a notable gap in understanding less-publicized infections like human papillomavirus (HPV) and syphilis. Furthermore, misconceptions about transmission routes and preventive measures persist, highlighting the need for improved sexual health education. This research emphasizes the importance of comprehensive sexual health programs in universities to bridge knowledge gaps and foster safer sexual practices among students. The study also suggests targeted interventions to address the cultural and social barriers that may hinder STI awareness and prevention efforts.